| Defiance to Southern Pines (North Carolina) | 499.27 mi (803.50 km) |
| Defiance to Southfield (Michigan) | 100.26 mi (161.35 km) |
| Defiance to Southgate (Michigan) | 87.44 mi (140.73 km) |
| Defiance to Southlake (Texas) | 907.74 mi (1,460.87 km) |
| Defiance to Spanaway (Washington) | 1,907.97 mi (3,070.57 km) |
| Defiance to Spanish Fork (Utah) | 1,425.22 mi (2,293.66 km) |
| Defiance to Spanish Lake (Missouri) | 353.69 mi (569.21 km) |
| Defiance to Spanish Springs (Nevada) | 1,846.27 mi (2,971.29 km) |
| Defiance to Sparks (Nevada) | 1,850.17 mi (2,977.57 km) |
| Defiance to Spartanburg (South Carolina) | 457.45 mi (736.20 km) |
| Defiance to Spearfish (South Dakota) | 1,006.71 mi (1,620.15 km) |
| Defiance to Speedway (Indiana) | 142.59 mi (229.48 km) |
| Defiance to Spencer (Iowa) | 566.45 mi (911.61 km) |
| Defiance to Spokane (Washington) | 1,674.89 mi (2,695.47 km) |
| Defiance to Spokane Valley (Washington) | 1,665.65 mi (2,680.61 km) |
