| Defiance to Somersworth (New Hampshire) | 701.75 mi (1,129.36 km) |
| Defiance to Somerton (Arizona) | 1,768.40 mi (2,845.96 km) |
| Defiance to Somerville (Massachusetts) | 686.40 mi (1,104.66 km) |
| Defiance to Somerville (New Jersey) | 511.43 mi (823.06 km) |
| Defiance to Sonoma (California) | 2,016.86 mi (3,245.82 km) |
| Defiance to Soquel (California) | 2,019.69 mi (3,250.38 km) |
| Defiance to South Bend (Indiana) | 102.27 mi (164.59 km) |
| Defiance to South Bradenton (Florida) | 960.22 mi (1,545.32 km) |
| Defiance to South Burlington (Vermont) | 605.03 mi (973.70 km) |
| Defiance to South Charleston (West Virginia) | 246.97 mi (397.47 km) |
| Defiance to South Daytona (Florida) | 858.13 mi (1,381.02 km) |
| Defiance to South El Monte (California) | 1,895.73 mi (3,050.88 km) |
| Defiance to South Elgin (Illinois) | 209.65 mi (337.39 km) |
| Defiance to South Euclid (Ohio) | 148.19 mi (238.49 km) |
| Defiance to South Farmingdale (New York) | 570.30 mi (917.81 km) |
