| Defiance to Smyrna (Delaware) | 481.31 mi (774.59 km) |
| Defiance to Smyrna (Georgia) | 512.60 mi (824.95 km) |
| Defiance to Smyrna (Tennessee) | 385.11 mi (619.78 km) |
| Defiance to Snellville (Georgia) | 513.41 mi (826.25 km) |
| Defiance to Snoqualmie (Washington) | 1,880.02 mi (3,025.60 km) |
| Defiance to Snyder (Texas) | 1,085.26 mi (1,746.55 km) |
| Defiance to Socastee (South Carolina) | 601.01 mi (967.23 km) |
| Defiance to Socorro (Texas) | 1,381.50 mi (2,223.31 km) |
| Defiance to Soddy-Daisy (Tennessee) | 418.53 mi (673.56 km) |
| Defiance to Solana Beach (California) | 1,887.06 mi (3,036.93 km) |
| Defiance to Soledad (California) | 2,001.79 mi (3,221.58 km) |
| Defiance to Solon (Ohio) | 151.95 mi (244.54 km) |
| Defiance to Somers Point (New Jersey) | 531.55 mi (855.45 km) |
| Defiance to Somerset (Kentucky) | 290.34 mi (467.26 km) |
| Defiance to Somerset (New Jersey) | 517.70 mi (833.15 km) |
