| Defiance to Silver Firs (Washington) | 1,894.17 mi (3,048.37 km) |
| Defiance to Silver Spring (Maryland) | 418.50 mi (673.51 km) |
| Defiance to Silver Springs Shores (Florida) | 851.09 mi (1,369.70 km) |
| Defiance to Silverdale (Washington) | 1,919.08 mi (3,088.46 km) |
| Defiance to Silverton (Oregon) | 1,935.27 mi (3,114.51 km) |
| Defiance to Simi Valley (California) | 1,925.68 mi (3,099.09 km) |
| Defiance to Simpsonville (South Carolina) | 467.03 mi (751.61 km) |
| Defiance to Sioux City (Iowa) | 623.61 mi (1,003.61 km) |
| Defiance to Sioux Falls (South Dakota) | 649.14 mi (1,044.68 km) |
| Defiance to Skokie (Illinois) | 181.81 mi (292.59 km) |
| Defiance to Sleepy Hollow (New York) | 545.45 mi (877.82 km) |
| Defiance to Slidell (Louisiana) | 817.50 mi (1,315.64 km) |
| Defiance to Smithfield (North Carolina) | 514.45 mi (827.93 km) |
| Defiance to Smithfield (Utah) | 1,414.21 mi (2,275.95 km) |
| Defiance to Smithville (Missouri) | 552.93 mi (889.86 km) |
