| Defiance to Shoreview (Minnesota) | 513.64 mi (826.63 km) |
| Defiance to Shorewood (Illinois) | 200.13 mi (322.08 km) |
| Defiance to Shorewood (Wisconsin) | 219.35 mi (353.01 km) |
| Defiance to Short Hills (New Jersey) | 524.40 mi (843.93 km) |
| Defiance to Short Pump (Virginia) | 438.23 mi (705.26 km) |
| Defiance to Show Low (Arizona) | 1,476.93 mi (2,376.89 km) |
| Defiance to Shreveport (Louisiana) | 800.64 mi (1,288.51 km) |
| Defiance to Sicklerville (New Jersey) | 503.35 mi (810.07 km) |
| Defiance to Sidney (Ohio) | 69.34 mi (111.59 km) |
| Defiance to Sierra Madre (California) | 1,892.33 mi (3,045.41 km) |
| Defiance to Sierra Vista (Arizona) | 1,583.17 mi (2,547.87 km) |
| Defiance to Sierra Vista Southeast (Arizona) | 1,582.35 mi (2,546.54 km) |
| Defiance to Signal Hill (California) | 1,909.24 mi (3,072.62 km) |
| Defiance to Sikeston (Missouri) | 412.98 mi (664.63 km) |
| Defiance to Siloam Springs (Arkansas) | 650.64 mi (1,047.11 km) |
