| Defiance to Shelton (Connecticut) | 582.44 mi (937.34 km) |
| Defiance to Shelton (Washington) | 1,940.01 mi (3,122.14 km) |
| Defiance to Shenandoah (Louisiana) | 837.90 mi (1,348.48 km) |
| Defiance to Shepherdsville (Kentucky) | 238.81 mi (384.33 km) |
| Defiance to Sheridan (Wyoming) | 1,162.74 mi (1,871.25 km) |
| Defiance to Sherman (Texas) | 853.87 mi (1,374.17 km) |
| Defiance to Sherrelwood (Colorado) | 1,085.21 mi (1,746.47 km) |
| Defiance to Sherwood (Arkansas) | 615.23 mi (990.12 km) |
| Defiance to Sherwood (Oregon) | 1,935.77 mi (3,115.33 km) |
| Defiance to Shiloh (Illinois) | 349.23 mi (562.02 km) |
| Defiance to Shiloh (Ohio) | 101.49 mi (163.34 km) |
| Defiance to Shiloh (Pennsylvania) | 407.17 mi (655.27 km) |
| Defiance to Shirley (New York) | 599.37 mi (964.59 km) |
| Defiance to Shively (Kentucky) | 226.55 mi (364.60 km) |
| Defiance to Shoreline (Washington) | 1,903.18 mi (3,062.87 km) |
