| Defiance to Seymour (Tennessee) | 374.71 mi (603.03 km) |
| Defiance to Shady Hills (Florida) | 895.62 mi (1,441.36 km) |
| Defiance to Shafter (California) | 1,915.42 mi (3,082.58 km) |
| Defiance to Shaker Heights (Ohio) | 146.60 mi (235.94 km) |
| Defiance to Shakopee (Minnesota) | 519.23 mi (835.62 km) |
| Defiance to Sharon (Pennsylvania) | 200.81 mi (323.17 km) |
| Defiance to Sharonville (Ohio) | 138.12 mi (222.28 km) |
| Defiance to Shasta Lake (California) | 1,967.15 mi (3,165.82 km) |
| Defiance to Shawnee (Kansas) | 572.84 mi (921.90 km) |
| Defiance to Shawnee (Oklahoma) | 795.19 mi (1,279.73 km) |
| Defiance to Sheboygan (Wisconsin) | 241.32 mi (388.37 km) |
| Defiance to Shelby (North Carolina) | 441.22 mi (710.08 km) |
| Defiance to Shelbyville (Indiana) | 141.72 mi (228.08 km) |
| Defiance to Shelbyville (Kentucky) | 217.33 mi (349.75 km) |
| Defiance to Shelbyville (Tennessee) | 415.16 mi (668.14 km) |
