| Defiance to Security-Widefield (Colorado) | 1,088.31 mi (1,751.46 km) |
| Defiance to Sedalia (Missouri) | 501.73 mi (807.45 km) |
| Defiance to Sedro-Woolley (Washington) | 1,898.21 mi (3,054.88 km) |
| Defiance to Seguin (Texas) | 1,110.35 mi (1,786.94 km) |
| Defiance to Selden (New York) | 589.82 mi (949.22 km) |
| Defiance to Selma (Alabama) | 629.91 mi (1,013.74 km) |
| Defiance to Selma (California) | 1,908.96 mi (3,072.18 km) |
| Defiance to Selma (Texas) | 1,123.83 mi (1,808.63 km) |
| Defiance to Seminole (Florida) | 932.77 mi (1,501.14 km) |
| Defiance to Seven Hills (Ohio) | 139.84 mi (225.04 km) |
| Defiance to Seven Oaks (South Carolina) | 529.86 mi (852.72 km) |
| Defiance to Severn (Maryland) | 430.84 mi (693.37 km) |
| Defiance to Severna Park (Maryland) | 438.41 mi (705.55 km) |
| Defiance to Sevierville (Tennessee) | 375.17 mi (603.78 km) |
| Defiance to Seymour (Indiana) | 180.26 mi (290.10 km) |
