| Defiance to Scottsboro (Alabama) | 467.66 mi (752.62 km) |
| Defiance to Scottsdale (Arizona) | 1,588.37 mi (2,556.24 km) |
| Defiance to Scranton (Pennsylvania) | 451.23 mi (726.18 km) |
| Defiance to Seabrook (Maryland) | 427.49 mi (687.97 km) |
| Defiance to Seabrook (Texas) | 1,005.35 mi (1,617.95 km) |
| Defiance to Seaford (New York) | 568.43 mi (914.80 km) |
| Defiance to Seagoville (Texas) | 896.98 mi (1,443.55 km) |
| Defiance to Seal Beach (California) | 1,905.70 mi (3,066.92 km) |
| Defiance to Searcy (Arkansas) | 577.46 mi (929.33 km) |
| Defiance to Seaside (California) | 2,022.12 mi (3,254.29 km) |
| Defiance to SeaTac (Washington) | 1,901.47 mi (3,060.12 km) |
| Defiance to Seattle (Washington) | 1,902.45 mi (3,061.70 km) |
| Defiance to Sebastian (Florida) | 958.25 mi (1,542.15 km) |
| Defiance to Sebring (Florida) | 967.97 mi (1,557.80 km) |
| Defiance to Secaucus (New Jersey) | 537.63 mi (865.23 km) |
