| Defiance to Savannah (Georgia) | 663.07 mi (1,067.11 km) |
| Defiance to Sayreville (New Jersey) | 527.37 mi (848.71 km) |
| Defiance to Sayville (New York) | 588.90 mi (947.74 km) |
| Defiance to Scaggsville (Maryland) | 421.35 mi (678.10 km) |
| Defiance to Scarsdale (New York) | 551.02 mi (886.79 km) |
| Defiance to Schaumburg (Illinois) | 198.78 mi (319.91 km) |
| Defiance to Schenectady (New York) | 545.45 mi (877.81 km) |
| Defiance to Schererville (Indiana) | 160.21 mi (257.83 km) |
| Defiance to Schertz (Texas) | 1,122.65 mi (1,806.74 km) |
| Defiance to Schiller Park (Illinois) | 186.90 mi (300.79 km) |
| Defiance to Schofield Barracks (Hawaii) | 4,423.48 mi (7,118.91 km) |
| Defiance to Scotchtown (New York) | 518.27 mi (834.08 km) |
| Defiance to Scottdale (Georgia) | 517.28 mi (832.49 km) |
| Defiance to Scotts Valley (California) | 2,021.60 mi (3,253.46 km) |
| Defiance to Scottsbluff (Nebraska) | 996.09 mi (1,603.05 km) |
