| Defiance to Santa Rosa (California) | 2,026.26 mi (3,260.95 km) |
| Defiance to Santaquin (Utah) | 1,435.21 mi (2,309.75 km) |
| Defiance to Santee (California) | 1,877.44 mi (3,021.45 km) |
| Defiance to Sapulpa (Oklahoma) | 729.60 mi (1,174.18 km) |
| Defiance to Saraland (Alabama) | 750.24 mi (1,207.39 km) |
| Defiance to Sarasota (Florida) | 968.87 mi (1,559.25 km) |
| Defiance to Sarasota Springs (Florida) | 971.36 mi (1,563.25 km) |
| Defiance to Saratoga (California) | 2,017.34 mi (3,246.60 km) |
| Defiance to Saratoga Springs (New York) | 555.63 mi (894.19 km) |
| Defiance to Saratoga Springs (Utah) | 1,436.06 mi (2,311.11 km) |
| Defiance to Sartell (Minnesota) | 577.45 mi (929.32 km) |
| Defiance to Satellite Beach (Florida) | 929.96 mi (1,496.62 km) |
| Defiance to Sauk Rapids (Minnesota) | 573.93 mi (923.65 km) |
| Defiance to Sault Ste. Marie (Michigan) | 359.31 mi (578.26 km) |
| Defiance to Savage (Minnesota) | 513.57 mi (826.51 km) |
