| Defiance to Sanford (Maine) | 709.59 mi (1,141.98 km) |
| Defiance to Sanford (North Carolina) | 488.88 mi (786.78 km) |
| Defiance to Sanger (California) | 1,902.91 mi (3,062.44 km) |
| Defiance to Santa Ana (California) | 1,896.42 mi (3,051.99 km) |
| Defiance to Santa Barbara (California) | 1,971.38 mi (3,172.63 km) |
| Defiance to Santa Clara (California) | 2,012.09 mi (3,238.15 km) |
| Defiance to Santa Clara (Oregon) | 1,960.07 mi (3,154.42 km) |
| Defiance to Santa Clarita (California) | 1,908.23 mi (3,071.00 km) |
| Defiance to Santa Cruz (California) | 2,024.61 mi (3,258.29 km) |
| Defiance to Santa Fe (New Mexico) | 1,228.23 mi (1,976.64 km) |
| Defiance to Santa Fe (Texas) | 1,018.63 mi (1,639.32 km) |
| Defiance to Santa Fe Springs (California) | 1,899.90 mi (3,057.60 km) |
| Defiance to Santa Maria (California) | 1,994.71 mi (3,210.18 km) |
| Defiance to Santa Monica (California) | 1,918.89 mi (3,088.16 km) |
| Defiance to Santa Paula (California) | 1,939.55 mi (3,121.41 km) |
