| Defiance to San Luis Obispo (California) | 1,997.33 mi (3,214.39 km) |
| Defiance to San Marcos (California) | 1,878.35 mi (3,022.91 km) |
| Defiance to San Marcos (Texas) | 1,094.07 mi (1,760.73 km) |
| Defiance to San Marino (California) | 1,896.94 mi (3,052.82 km) |
| Defiance to San Mateo (California) | 2,025.57 mi (3,259.84 km) |
| Defiance to San Pablo (California) | 2,017.93 mi (3,247.54 km) |
| Defiance to San Rafael (California) | 2,026.58 mi (3,261.47 km) |
| Defiance to San Ramon (California) | 2,001.41 mi (3,220.95 km) |
| Defiance to San Tan Valley (Arizona) | 1,589.42 mi (2,557.92 km) |
| Defiance to Sand Springs (Oklahoma) | 726.14 mi (1,168.61 km) |
| Defiance to Sandusky (Ohio) | 87.01 mi (140.02 km) |
| Defiance to Sandy (Oregon) | 1,907.83 mi (3,070.36 km) |
| Defiance to Sandy (Utah) | 1,429.65 mi (2,300.81 km) |
| Defiance to Sandy Springs (Georgia) | 507.47 mi (816.69 km) |
| Defiance to Sanford (Florida) | 880.48 mi (1,417.00 km) |
