| Defiance to Reidsville (North Carolina) | 424.73 mi (683.53 km) |
| Defiance to Reisterstown (Maryland) | 416.92 mi (670.96 km) |
| Defiance to Rendon (Texas) | 929.17 mi (1,495.35 km) |
| Defiance to Reno (Nevada) | 1,857.40 mi (2,989.20 km) |
| Defiance to Renton (Washington) | 1,896.43 mi (3,052.02 km) |
| Defiance to Republic (Missouri) | 563.37 mi (906.65 km) |
| Defiance to Reston (Virginia) | 404.22 mi (650.53 km) |
| Defiance to Revere (Massachusetts) | 691.44 mi (1,112.76 km) |
| Defiance to Rexburg (Idaho) | 1,400.44 mi (2,253.79 km) |
| Defiance to Reynoldsburg (Ohio) | 123.05 mi (198.02 km) |
| Defiance to Rialto (California) | 1,859.60 mi (2,992.73 km) |
| Defiance to Richardson (Texas) | 888.35 mi (1,429.66 km) |
| Defiance to Richfield (Minnesota) | 513.60 mi (826.56 km) |
| Defiance to Richfield (Wisconsin) | 239.83 mi (385.97 km) |
| Defiance to Richland (Washington) | 1,761.35 mi (2,834.62 km) |
