| Defiance to Orangevale (California) | 1,944.68 mi (3,129.65 km) |
| Defiance to Orchards (Washington) | 1,918.70 mi (3,087.85 km) |
| Defiance to Orcutt (California) | 1,995.41 mi (3,211.30 km) |
| Defiance to Oregon (Ohio) | 54.72 mi (88.06 km) |
| Defiance to Oregon (Wisconsin) | 281.40 mi (452.86 km) |
| Defiance to Oregon City (Oregon) | 1,923.79 mi (3,096.04 km) |
| Defiance to Orem (Utah) | 1,425.57 mi (2,294.23 km) |
| Defiance to Orinda (California) | 2,011.30 mi (3,236.87 km) |
| Defiance to Orland Park (Illinois) | 182.46 mi (293.64 km) |
| Defiance to Orlando (Florida) | 901.00 mi (1,450.03 km) |
| Defiance to Ormond Beach (Florida) | 847.97 mi (1,364.67 km) |
| Defiance to Oro Valley (Arizona) | 1,585.46 mi (2,551.55 km) |
| Defiance to Oroville (California) | 1,946.39 mi (3,132.42 km) |
| Defiance to Oshkosh (Wisconsin) | 285.14 mi (458.90 km) |
| Defiance to Oskaloosa (Iowa) | 429.44 mi (691.12 km) |
