| Defiance to Odessa (Texas) | 1,186.66 mi (1,909.74 km) |
| Defiance to Ogden (Utah) | 1,427.67 mi (2,297.62 km) |
| Defiance to Oildale (California) | 1,907.90 mi (3,070.46 km) |
| Defiance to Ojus (Florida) | 1,085.77 mi (1,747.37 km) |
| Defiance to Okemos (Michigan) | 98.45 mi (158.44 km) |
| Defiance to Oklahoma City (Oklahoma) | 816.36 mi (1,313.80 km) |
| Defiance to Okmulgee (Oklahoma) | 740.75 mi (1,192.12 km) |
| Defiance to Olathe (Kansas) | 576.54 mi (927.85 km) |
| Defiance to Old Jamestown (Missouri) | 355.47 mi (572.07 km) |
| Defiance to Oldsmar (Florida) | 919.16 mi (1,479.25 km) |
| Defiance to Olean (New York) | 311.08 mi (500.63 km) |
| Defiance to Olive Branch (Mississippi) | 528.38 mi (850.34 km) |
| Defiance to Olivehurst (California) | 1,954.12 mi (3,144.86 km) |
| Defiance to Olney (Maryland) | 411.99 mi (663.03 km) |
| Defiance to Olympia (Washington) | 1,930.34 mi (3,106.58 km) |
