| Defiance to McKeesport (Pennsylvania) | 245.17 mi (394.57 km) |
| Defiance to McKinleyville (California) | 2,049.36 mi (3,298.13 km) |
| Defiance to McKinney (Texas) | 875.64 mi (1,409.21 km) |
| Defiance to McLean (Virginia) | 411.76 mi (662.67 km) |
| Defiance to McMinnville (Oregon) | 1,953.68 mi (3,144.15 km) |
| Defiance to McMinnville (Tennessee) | 394.06 mi (634.18 km) |
| Defiance to McNair (Virginia) | 401.01 mi (645.36 km) |
| Defiance to McPherson (Kansas) | 732.70 mi (1,179.17 km) |
| Defiance to Mead Valley (California) | 1,862.66 mi (2,997.66 km) |
| Defiance to Meadow Woods (Florida) | 908.21 mi (1,461.63 km) |
| Defiance to Meadowbrook (Virginia) | 454.03 mi (730.70 km) |
| Defiance to Meadville (Pennsylvania) | 219.88 mi (353.86 km) |
| Defiance to Mebane (North Carolina) | 451.83 mi (727.15 km) |
| Defiance to Mechanicsville (Virginia) | 451.00 mi (725.82 km) |
| Defiance to Medford (Massachusetts) | 686.11 mi (1,104.19 km) |
