| Defiance to Indianola (Iowa) | 477.17 mi (767.93 km) |
| Defiance to Indio (California) | 1,811.37 mi (2,915.12 km) |
| Defiance to Inglewood (California) | 1,913.79 mi (3,079.95 km) |
| Defiance to Inkster (Michigan) | 88.44 mi (142.33 km) |
| Defiance to Inver Grove Heights (Minnesota) | 502.21 mi (808.22 km) |
| Defiance to Inwood (New York) | 555.46 mi (893.92 km) |
| Defiance to Iona (Florida) | 1,029.35 mi (1,656.58 km) |
| Defiance to Ionia (Michigan) | 122.65 mi (197.39 km) |
| Defiance to Iowa City (Iowa) | 371.73 mi (598.24 km) |
| Defiance to Irmo (South Carolina) | 525.36 mi (845.48 km) |
| Defiance to Irondale (Alabama) | 549.18 mi (883.81 km) |
| Defiance to Ironton (Ohio) | 209.94 mi (337.86 km) |
| Defiance to Irvine (California) | 1,892.62 mi (3,045.88 km) |
| Defiance to Irving (Texas) | 904.70 mi (1,455.97 km) |
| Defiance to Isabela (Puerto Rico) | 1,877.90 mi (3,022.19 km) |
