| Defiance to Hutchinson (Minnesota) | 562.69 mi (905.57 km) |
| Defiance to Hutto (Texas) | 1,043.91 mi (1,680.02 km) |
| Defiance to Hyattsville (Maryland) | 422.91 mi (680.61 km) |
| Defiance to Hybla Valley (Virginia) | 423.11 mi (680.93 km) |
| Defiance to Idaho Falls (Idaho) | 1,413.79 mi (2,275.28 km) |
| Defiance to Idylwood (Virginia) | 412.83 mi (664.38 km) |
| Defiance to Ilchester (Maryland) | 425.05 mi (684.06 km) |
| Defiance to Immokalee (Florida) | 1,040.04 mi (1,673.79 km) |
| Defiance to Imperial (California) | 1,805.32 mi (2,905.39 km) |
| Defiance to Imperial Beach (California) | 1,893.48 mi (3,047.26 km) |
| Defiance to Independence (Kentucky) | 161.30 mi (259.59 km) |
| Defiance to Independence (Missouri) | 548.04 mi (881.98 km) |
| Defiance to Indian Trail (North Carolina) | 474.24 mi (763.21 km) |
| Defiance to Indiana (Pennsylvania) | 275.65 mi (443.61 km) |
| Defiance to Indianapolis (Indiana) | 139.78 mi (224.96 km) |
