| Defiance to Firestone (Colorado) | 1,078.17 mi (1,735.15 km) |
| Defiance to Fish Hawk (Florida) | 935.87 mi (1,506.14 km) |
| Defiance to Fishers (Indiana) | 124.06 mi (199.66 km) |
| Defiance to Fitchburg (Massachusetts) | 650.75 mi (1,047.27 km) |
| Defiance to Fitchburg (Wisconsin) | 284.69 mi (458.16 km) |
| Defiance to Five Corners (Washington) | 1,920.78 mi (3,091.20 km) |
| Defiance to Five Forks (South Carolina) | 462.18 mi (743.81 km) |
| Defiance to Flagstaff (Arizona) | 1,530.74 mi (2,463.49 km) |
| Defiance to Flat Rock (Michigan) | 79.87 mi (128.54 km) |
| Defiance to Fleming Island (Florida) | 786.74 mi (1,266.13 km) |
| Defiance to Flint (Michigan) | 125.23 mi (201.53 km) |
| Defiance to Floral Park (New York) | 556.98 mi (896.38 km) |
| Defiance to Florence (Alabama) | 480.41 mi (773.15 km) |
| Defiance to Florence (Arizona) | 1,586.17 mi (2,552.69 km) |
| Defiance to Florence (Kentucky) | 159.02 mi (255.91 km) |
