| Defiance to Euless (Texas) | 909.68 mi (1,463.98 km) |
| Defiance to Eureka (California) | 2,055.55 mi (3,308.09 km) |
| Defiance to Eureka (Missouri) | 384.40 mi (618.63 km) |
| Defiance to Eustis (Florida) | 871.71 mi (1,402.89 km) |
| Defiance to Evans (Colorado) | 1,064.64 mi (1,713.37 km) |
| Defiance to Evans (Georgia) | 547.17 mi (880.58 km) |
| Defiance to Evanston (Illinois) | 179.75 mi (289.27 km) |
| Defiance to Evanston (Wyoming) | 1,375.84 mi (2,214.20 km) |
| Defiance to Evansville (Indiana) | 283.14 mi (455.68 km) |
| Defiance to Everett (Massachusetts) | 688.83 mi (1,108.57 km) |
| Defiance to Everett (Washington) | 1,894.94 mi (3,049.62 km) |
| Defiance to Evergreen Park (Illinois) | 175.25 mi (282.04 km) |
| Defiance to Ewa Beach (Hawaii) | 4,427.92 mi (7,126.05 km) |
| Defiance to Ewa Gentry (Hawaii) | 4,428.22 mi (7,126.54 km) |
| Defiance to Excelsior Springs (Missouri) | 536.94 mi (864.13 km) |
