| Defiance to Enumclaw (Washington) | 1,887.39 mi (3,037.46 km) |
| Defiance to Ephrata (Pennsylvania) | 435.04 mi (700.12 km) |
| Defiance to Erie (Colorado) | 1,084.41 mi (1,745.18 km) |
| Defiance to Erie (Pennsylvania) | 228.81 mi (368.23 km) |
| Defiance to Erlanger (Kentucky) | 157.30 mi (253.15 km) |
| Defiance to Escanaba (Michigan) | 337.39 mi (542.97 km) |
| Defiance to Escondido (California) | 1,873.10 mi (3,014.46 km) |
| Defiance to Española (New Mexico) | 1,222.86 mi (1,968.01 km) |
| Defiance to Essex (Maryland) | 439.07 mi (706.62 km) |
| Defiance to Essex Junction (Vermont) | 610.60 mi (982.67 km) |
| Defiance to Estelle (Louisiana) | 852.91 mi (1,372.62 km) |
| Defiance to Estero (Florida) | 1,036.70 mi (1,668.40 km) |
| Defiance to Euclid (Ohio) | 149.00 mi (239.79 km) |
| Defiance to Eufaula (Alabama) | 648.93 mi (1,044.36 km) |
| Defiance to Eugene (Oregon) | 1,959.80 mi (3,153.99 km) |
