| Defiance to Emeryville (California) | 2,018.14 mi (3,247.89 km) |
| Defiance to Emmaus (Pennsylvania) | 465.72 mi (749.50 km) |
| Defiance to Emporia (Kansas) | 657.59 mi (1,058.29 km) |
| Defiance to Encinitas (California) | 1,885.51 mi (3,034.44 km) |
| Defiance to Endicott (New York) | 431.86 mi (695.02 km) |
| Defiance to Endwell (New York) | 434.13 mi (698.66 km) |
| Defiance to Englewood (Colorado) | 1,087.66 mi (1,750.42 km) |
| Defiance to Englewood (Florida) | 995.30 mi (1,601.78 km) |
| Defiance to Englewood (New Jersey) | 541.53 mi (871.51 km) |
| Defiance to Englewood (Ohio) | 97.95 mi (157.64 km) |
| Defiance to Enid (Oklahoma) | 799.79 mi (1,287.15 km) |
| Defiance to Ennis (Texas) | 916.77 mi (1,475.39 km) |
| Defiance to Ensley (Florida) | 760.60 mi (1,224.07 km) |
| Defiance to Enterprise (Alabama) | 692.63 mi (1,114.68 km) |
| Defiance to Enterprise (Nevada) | 1,695.33 mi (2,728.36 km) |
