| Defiance to Elkhorn (Wisconsin) | 234.80 mi (377.87 km) |
| Defiance to Elko (Nevada) | 1,627.29 mi (2,618.87 km) |
| Defiance to Elkridge (Maryland) | 426.96 mi (687.12 km) |
| Defiance to Elkton (Maryland) | 463.75 mi (746.33 km) |
| Defiance to Ellensburg (Washington) | 1,819.85 mi (2,928.76 km) |
| Defiance to Ellicott City (Maryland) | 420.26 mi (676.34 km) |
| Defiance to Elmhurst (Illinois) | 189.69 mi (305.28 km) |
| Defiance to Elmira (New York) | 393.76 mi (633.69 km) |
| Defiance to Elmont (New York) | 556.91 mi (896.25 km) |
| Defiance to Elmwood Park (Illinois) | 183.69 mi (295.62 km) |
| Defiance to Elmwood Park (New Jersey) | 533.83 mi (859.11 km) |
| Defiance to Elon (North Carolina) | 443.33 mi (713.47 km) |
| Defiance to Eloy (Arizona) | 1,605.69 mi (2,584.10 km) |
| Defiance to Elwood (New York) | 574.84 mi (925.11 km) |
| Defiance to Elyria (Ohio) | 117.42 mi (188.97 km) |
