| Defiance to El Sobrante (California) | 1,870.65 mi (3,010.52 km) |
| Defiance to Eldersburg (Maryland) | 411.20 mi (661.76 km) |
| Defiance to Elfers (Florida) | 907.62 mi (1,460.67 km) |
| Defiance to Elgin (Illinois) | 210.89 mi (339.40 km) |
| Defiance to Elizabeth (New Jersey) | 532.15 mi (856.42 km) |
| Defiance to Elizabeth City (North Carolina) | 556.73 mi (895.97 km) |
| Defiance to Elizabethton (Tennessee) | 360.32 mi (579.87 km) |
| Defiance to Elizabethtown (Kentucky) | 260.02 mi (418.47 km) |
| Defiance to Elizabethtown (Pennsylvania) | 413.98 mi (666.23 km) |
| Defiance to Elk City (Oklahoma) | 910.67 mi (1,465.59 km) |
| Defiance to Elk Grove (California) | 1,958.72 mi (3,152.25 km) |
| Defiance to Elk Grove Village (Illinois) | 193.81 mi (311.91 km) |
| Defiance to Elk Plain (Washington) | 1,905.42 mi (3,066.47 km) |
| Defiance to Elk River (Minnesota) | 540.18 mi (869.33 km) |
| Defiance to Elkhart (Indiana) | 87.38 mi (140.63 km) |
