| Defiance to Eggertsville (New York) | 307.68 mi (495.17 km) |
| Defiance to Egypt Lake-Leto (Florida) | 922.43 mi (1,484.51 km) |
| Defiance to El Cajon (California) | 1,877.89 mi (3,022.17 km) |
| Defiance to El Campo (Texas) | 1,069.35 mi (1,720.95 km) |
| Defiance to El Centro (California) | 1,806.38 mi (2,907.09 km) |
| Defiance to El Cerrito (California) | 2,016.81 mi (3,245.75 km) |
| Defiance to El Dorado (Arkansas) | 719.43 mi (1,157.80 km) |
| Defiance to El Dorado (Kansas) | 706.54 mi (1,137.06 km) |
| Defiance to El Dorado Hills (California) | 1,936.08 mi (3,115.83 km) |
| Defiance to El Mirage (Arizona) | 1,615.05 mi (2,599.17 km) |
| Defiance to El Monte (California) | 1,894.00 mi (3,048.11 km) |
| Defiance to El Paso (Texas) | 1,381.49 mi (2,223.29 km) |
| Defiance to El Paso de Robles (California) | 1,986.72 mi (3,197.31 km) |
| Defiance to El Reno (Oklahoma) | 834.90 mi (1,343.64 km) |
| Defiance to El Segundo (California) | 1,917.94 mi (3,086.63 km) |
