| Defiance to Eau Claire (Wisconsin) | 434.86 mi (699.85 km) |
| Defiance to Echelon (New Jersey) | 501.42 mi (806.95 km) |
| Defiance to Eden (North Carolina) | 413.21 mi (664.99 km) |
| Defiance to Eden Prairie (Minnesota) | 520.60 mi (837.82 km) |
| Defiance to Edgewater (Florida) | 872.88 mi (1,404.77 km) |
| Defiance to Edgewater (New Jersey) | 542.04 mi (872.34 km) |
| Defiance to Edgewood (Maryland) | 443.76 mi (714.16 km) |
| Defiance to Edgewood (Washington) | 1,901.10 mi (3,059.53 km) |
| Defiance to Edina (Minnesota) | 517.46 mi (832.78 km) |
| Defiance to Edinburg (Texas) | 1,298.67 mi (2,090.01 km) |
| Defiance to Edmond (Oklahoma) | 804.17 mi (1,294.19 km) |
| Defiance to Edmonds (Washington) | 1,903.64 mi (3,063.60 km) |
| Defiance to Edwards (Colorado) | 1,172.35 mi (1,886.72 km) |
| Defiance to Edwardsville (Illinois) | 343.43 mi (552.70 km) |
| Defiance to Effingham (Illinois) | 266.54 mi (428.95 km) |
