| Defiance to Dumas (Texas) | 1,019.44 mi (1,640.63 km) |
| Defiance to Dumont (New Jersey) | 540.17 mi (869.32 km) |
| Defiance to Duncan (Oklahoma) | 871.90 mi (1,403.19 km) |
| Defiance to Duncanville (Texas) | 912.49 mi (1,468.51 km) |
| Defiance to Dundalk (Maryland) | 437.39 mi (703.91 km) |
| Defiance to Dunedin (Florida) | 919.72 mi (1,480.15 km) |
| Defiance to Dunkirk (New York) | 271.80 mi (437.42 km) |
| Defiance to Dunmore (Pennsylvania) | 454.19 mi (730.96 km) |
| Defiance to Dunwoody (Georgia) | 507.12 mi (816.13 km) |
| Defiance to Durango (Colorado) | 1,283.61 mi (2,065.77 km) |
| Defiance to Durant (Oklahoma) | 827.18 mi (1,331.22 km) |
| Defiance to Durham (North Carolina) | 470.06 mi (756.49 km) |
| Defiance to Dyer (Indiana) | 163.61 mi (263.31 km) |
| Defiance to Dyersburg (Tennessee) | 451.41 mi (726.47 km) |
| Defiance to Eagan (Minnesota) | 506.57 mi (815.24 km) |
