| Defiance to Desert Hot Springs (California) | 1,820.65 mi (2,930.05 km) |
| Defiance to DeSoto (Texas) | 912.71 mi (1,468.86 km) |
| Defiance to Destin (Florida) | 761.28 mi (1,225.16 km) |
| Defiance to Destrehan (Louisiana) | 851.03 mi (1,369.60 km) |
| Defiance to Detroit (Michigan) | 100.14 mi (161.16 km) |
| Defiance to Diamond Bar (California) | 1,885.18 mi (3,033.91 km) |
| Defiance to Diamond Springs (California) | 1,924.92 mi (3,097.86 km) |
| Defiance to Dickinson (North Dakota) | 990.22 mi (1,593.61 km) |
| Defiance to Dickinson (Texas) | 1,013.45 mi (1,630.99 km) |
| Defiance to Dickson (Tennessee) | 395.11 mi (635.86 km) |
| Defiance to Difficult Run (Virginia) | 405.63 mi (652.79 km) |
| Defiance to Dinuba (California) | 1,898.42 mi (3,055.21 km) |
| Defiance to Discovery Bay (California) | 1,980.77 mi (3,187.74 km) |
| Defiance to Dix Hills (New York) | 575.26 mi (925.79 km) |
| Defiance to Dixon (California) | 1,980.80 mi (3,187.80 km) |
