| Defiance to Delhi (California) | 1,948.87 mi (3,136.40 km) |
| Defiance to Delray Beach (Florida) | 1,052.97 mi (1,694.59 km) |
| Defiance to Deltona (Florida) | 873.31 mi (1,405.46 km) |
| Defiance to Deming (New Mexico) | 1,430.35 mi (2,301.93 km) |
| Defiance to Denison (Texas) | 845.68 mi (1,360.99 km) |
| Defiance to Dent (Ohio) | 145.22 mi (233.71 km) |
| Defiance to Denton (Texas) | 895.09 mi (1,440.51 km) |
| Defiance to Dentsville (South Carolina) | 531.55 mi (855.45 km) |
| Defiance to Denver (Colorado) | 1,079.80 mi (1,737.77 km) |
| Defiance to Depew (New York) | 311.27 mi (500.93 km) |
| Defiance to Derby (Connecticut) | 585.20 mi (941.79 km) |
| Defiance to Derby (Kansas) | 733.64 mi (1,180.68 km) |
| Defiance to Des Moines (Iowa) | 479.13 mi (771.09 km) |
| Defiance to Des Moines (Washington) | 1,902.34 mi (3,061.52 km) |
| Defiance to Des Plaines (Illinois) | 189.75 mi (305.37 km) |
