| Defiance to Cloverleaf (Texas) | 998.13 mi (1,606.34 km) |
| Defiance to Cloverly (Maryland) | 416.63 mi (670.50 km) |
| Defiance to Clovis (California) | 1,906.32 mi (3,067.93 km) |
| Defiance to Clovis (New Mexico) | 1,127.47 mi (1,814.49 km) |
| Defiance to Clute (Texas) | 1,049.45 mi (1,688.92 km) |
| Defiance to Coachella (California) | 1,807.98 mi (2,909.67 km) |
| Defiance to Coalinga (California) | 1,956.51 mi (3,148.69 km) |
| Defiance to Coamo (Puerto Rico) | 1,924.62 mi (3,097.37 km) |
| Defiance to Coatesville (Pennsylvania) | 456.75 mi (735.07 km) |
| Defiance to Cockeysville (Maryland) | 425.59 mi (684.92 km) |
| Defiance to Cocoa (Florida) | 914.08 mi (1,471.07 km) |
| Defiance to Cocoa Beach (Florida) | 919.20 mi (1,479.30 km) |
| Defiance to Coconut Creek (Florida) | 1,063.56 mi (1,711.63 km) |
| Defiance to Coeur d'Alene (Idaho) | 1,645.34 mi (2,647.92 km) |
| Defiance to Cohoes (New York) | 556.24 mi (895.19 km) |
