| Defiance to Clarksdale (Mississippi) | 595.22 mi (957.91 km) |
| Defiance to Clarkston (Georgia) | 516.14 mi (830.65 km) |
| Defiance to Clarksville (Indiana) | 217.57 mi (350.15 km) |
| Defiance to Clarksville (Tennessee) | 362.68 mi (583.68 km) |
| Defiance to Clawson (Michigan) | 106.90 mi (172.04 km) |
| Defiance to Clay (Alabama) | 538.33 mi (866.36 km) |
| Defiance to Clayton (California) | 1,997.12 mi (3,214.06 km) |
| Defiance to Clayton (Missouri) | 364.52 mi (586.64 km) |
| Defiance to Clayton (North Carolina) | 503.04 mi (809.56 km) |
| Defiance to Clayton (Ohio) | 97.61 mi (157.08 km) |
| Defiance to Clearfield (Utah) | 1,431.95 mi (2,304.50 km) |
| Defiance to Clearlake (California) | 2,011.86 mi (3,237.77 km) |
| Defiance to Clearwater (Florida) | 923.56 mi (1,486.33 km) |
| Defiance to Cleburne (Texas) | 947.39 mi (1,524.68 km) |
| Defiance to Clemmons (North Carolina) | 421.37 mi (678.13 km) |
