| Defiance to Anoka (Minnesota) | 528.62 mi (850.73 km) |
| Defiance to Ansonia (Connecticut) | 585.87 mi (942.87 km) |
| Defiance to Antelope (California) | 1,951.34 mi (3,140.38 km) |
| Defiance to Anthem (Arizona) | 1,595.93 mi (2,568.40 km) |
| Defiance to Antioch (California) | 1,989.36 mi (3,201.56 km) |
| Defiance to Antioch (Illinois) | 207.70 mi (334.26 km) |
| Defiance to Apache Junction (Arizona) | 1,580.80 mi (2,544.06 km) |
| Defiance to Apex (North Carolina) | 485.17 mi (780.80 km) |
| Defiance to Apollo Beach (Florida) | 940.71 mi (1,513.92 km) |
| Defiance to Apopka (Florida) | 883.71 mi (1,422.20 km) |
| Defiance to Apple Valley (California) | 1,838.24 mi (2,958.36 km) |
| Defiance to Apple Valley (Minnesota) | 506.07 mi (814.44 km) |
| Defiance to Appleton (Wisconsin) | 290.62 mi (467.71 km) |
| Defiance to Arbutus (Maryland) | 428.22 mi (689.15 km) |
| Defiance to Arcadia (California) | 1,892.66 mi (3,045.94 km) |
