| Defiance to Altus (Oklahoma) | 931.81 mi (1,499.60 km) |
| Defiance to Alum Rock (California) | 2,004.52 mi (3,225.96 km) |
| Defiance to Alvin (Texas) | 1,025.17 mi (1,649.85 km) |
| Defiance to Amarillo (Texas) | 1,034.38 mi (1,664.67 km) |
| Defiance to Amelia (Ohio) | 155.95 mi (250.98 km) |
| Defiance to American Canyon (California) | 2,008.85 mi (3,232.92 km) |
| Defiance to American Fork (Utah) | 1,429.40 mi (2,300.40 km) |
| Defiance to Americus (Georgia) | 636.24 mi (1,023.93 km) |
| Defiance to Ames (Iowa) | 480.36 mi (773.07 km) |
| Defiance to Amherst (Ohio) | 111.08 mi (178.77 km) |
| Defiance to Ammon (Idaho) | 1,409.87 mi (2,268.97 km) |
| Defiance to Amsterdam (New York) | 533.65 mi (858.82 km) |
| Defiance to Anacortes (Washington) | 1,916.37 mi (3,084.10 km) |
| Defiance to Anaheim (California) | 1,892.08 mi (3,045.01 km) |
| Defiance to Anchorage (Alaska) | 2,963.86 mi (4,769.87 km) |
