| Defiance to Abilene (Texas) | 1,043.37 mi (1,679.14 km) |
| Defiance to Accokeek (Maryland) | 429.26 mi (690.83 km) |
| Defiance to Acworth (Georgia) | 499.46 mi (803.80 km) |
| Defiance to Ada (Oklahoma) | 805.59 mi (1,296.47 km) |
| Defiance to Addison (Illinois) | 193.46 mi (311.35 km) |
| Defiance to Addison (Texas) | 894.24 mi (1,439.15 km) |
| Defiance to Adelanto (California) | 1,848.77 mi (2,975.31 km) |
| Defiance to Adelphi (Maryland) | 421.26 mi (677.95 km) |
| Defiance to Adrian (Michigan) | 45.81 mi (73.73 km) |
| Defiance to Affton (Missouri) | 367.83 mi (591.97 km) |
| Defiance to Agoura Hills (California) | 1,929.66 mi (3,105.48 km) |
| Defiance to Aguadilla (Puerto Rico) | 1,877.36 mi (3,021.31 km) |
| Defiance to Aiken (South Carolina) | 554.70 mi (892.70 km) |
| Defiance to Akron (Ohio) | 148.53 mi (239.04 km) |
| Defiance to Alabaster (Alabama) | 573.08 mi (922.28 km) |
