| Darien to Southern Pines (North Carolina) | 647.65 mi (1,042.30 km) |
| Darien to Southfield (Michigan) | 247.21 mi (397.84 km) |
| Darien to Southgate (Michigan) | 247.37 mi (398.10 km) |
| Darien to Southlake (Texas) | 787.96 mi (1,268.10 km) |
| Darien to Spanaway (Washington) | 1,724.55 mi (2,775.39 km) |
| Darien to Spanish Fork (Utah) | 1,236.26 mi (1,989.57 km) |
| Darien to Spanish Lake (Missouri) | 235.55 mi (379.07 km) |
| Darien to Spanish Springs (Nevada) | 1,656.68 mi (2,666.16 km) |
| Darien to Sparks (Nevada) | 1,660.60 mi (2,672.48 km) |
| Darien to Spartanburg (South Carolina) | 572.81 mi (921.86 km) |
| Darien to Spearfish (South Dakota) | 819.35 mi (1,318.61 km) |
| Darien to Speedway (Indiana) | 162.49 mi (261.51 km) |
| Darien to Spencer (Iowa) | 378.10 mi (608.50 km) |
| Darien to Spokane (Washington) | 1,492.88 mi (2,402.55 km) |
| Darien to Spokane Valley (Washington) | 1,483.65 mi (2,387.71 km) |
