| Darien to Enumclaw (Washington) | 1,704.17 mi (2,742.59 km) |
| Darien to Ephrata (Pennsylvania) | 624.60 mi (1,005.19 km) |
| Darien to Erie (Colorado) | 897.17 mi (1,443.85 km) |
| Darien to Erie (Pennsylvania) | 407.20 mi (655.32 km) |
| Darien to Erlanger (Kentucky) | 260.01 mi (418.44 km) |
| Darien to Escanaba (Michigan) | 280.13 mi (450.83 km) |
| Darien to Escondido (California) | 1,693.21 mi (2,724.96 km) |
| Darien to Española (New Mexico) | 1,048.02 mi (1,686.63 km) |
| Darien to Essex (Maryland) | 628.45 mi (1,011.40 km) |
| Darien to Essex Junction (Vermont) | 772.28 mi (1,242.87 km) |
| Darien to Estelle (Louisiana) | 830.68 mi (1,336.85 km) |
| Darien to Estero (Florida) | 1,115.15 mi (1,794.66 km) |
| Darien to Euclid (Ohio) | 333.69 mi (537.03 km) |
| Darien to Eufaula (Alabama) | 697.20 mi (1,122.04 km) |
| Darien to Eugene (Oregon) | 1,771.94 mi (2,851.66 km) |
