| Dana Point to Southern Pines (North Carolina) | 2,174.55 mi (3,499.59 km) |
| Dana Point to Southfield (Michigan) | 1,960.45 mi (3,155.03 km) |
| Dana Point to Southgate (Michigan) | 1,961.03 mi (3,155.97 km) |
| Dana Point to Southlake (Texas) | 1,186.30 mi (1,909.17 km) |
| Dana Point to Spanaway (Washington) | 973.29 mi (1,566.36 km) |
| Dana Point to Spanish Fork (Utah) | 567.62 mi (913.49 km) |
| Dana Point to Spanish Lake (Missouri) | 1,570.92 mi (2,528.15 km) |
| Dana Point to Spanish Springs (Nevada) | 441.01 mi (709.73 km) |
| Dana Point to Sparks (Nevada) | 436.11 mi (701.86 km) |
| Dana Point to Spartanburg (South Carolina) | 2,035.62 mi (3,276.02 km) |
| Dana Point to Spearfish (South Dakota) | 1,062.62 mi (1,710.12 km) |
| Dana Point to Speedway (Indiana) | 1,787.53 mi (2,876.76 km) |
| Dana Point to Spencer (Iowa) | 1,386.65 mi (2,231.60 km) |
| Dana Point to Spokane (Washington) | 980.79 mi (1,578.43 km) |
| Dana Point to Spokane Valley (Washington) | 980.68 mi (1,578.25 km) |
