| Cypress Gardens to Southern Pines (North Carolina) | 514.50 mi (828.01 km) |
| Cypress Gardens to Southfield (Michigan) | 1,003.87 mi (1,615.57 km) |
| Cypress Gardens to Southgate (Michigan) | 984.91 mi (1,585.06 km) |
| Cypress Gardens to Southlake (Texas) | 981.11 mi (1,578.94 km) |
| Cypress Gardens to Spanaway (Washington) | 2,551.73 mi (4,106.62 km) |
| Cypress Gardens to Spanish Fork (Utah) | 1,895.37 mi (3,050.31 km) |
| Cypress Gardens to Spanish Lake (Missouri) | 891.71 mi (1,435.06 km) |
| Cypress Gardens to Spanish Springs (Nevada) | 2,303.68 mi (3,707.41 km) |
| Cypress Gardens to Sparks (Nevada) | 2,305.28 mi (3,709.99 km) |
| Cypress Gardens to Spartanburg (South Carolina) | 479.76 mi (772.09 km) |
| Cypress Gardens to Spearfish (South Dakota) | 1,668.54 mi (2,685.25 km) |
| Cypress Gardens to Speedway (Indiana) | 855.27 mi (1,376.42 km) |
| Cypress Gardens to Spencer (Iowa) | 1,287.70 mi (2,072.35 km) |
| Cypress Gardens to Spokane (Washington) | 2,344.72 mi (3,773.47 km) |
| Cypress Gardens to Spokane Valley (Washington) | 2,336.08 mi (3,759.56 km) |
