| Creve Coeur to Southern Pines (North Carolina) | 654.60 mi (1,053.47 km) |
| Creve Coeur to Southfield (Michigan) | 459.70 mi (739.81 km) |
| Creve Coeur to Southgate (Michigan) | 452.28 mi (727.88 km) |
| Creve Coeur to Southlake (Texas) | 544.43 mi (876.18 km) |
| Creve Coeur to Spanaway (Washington) | 1,706.62 mi (2,746.55 km) |
| Creve Coeur to Spanish Fork (Utah) | 1,133.69 mi (1,824.50 km) |
| Creve Coeur to Spanish Lake (Missouri) | 15.40 mi (24.78 km) |
| Creve Coeur to Spanish Springs (Nevada) | 1,560.38 mi (2,511.18 km) |
| Creve Coeur to Sparks (Nevada) | 1,563.54 mi (2,516.28 km) |
| Creve Coeur to Spartanburg (South Carolina) | 536.37 mi (863.20 km) |
| Creve Coeur to Spearfish (South Dakota) | 798.49 mi (1,285.04 km) |
| Creve Coeur to Speedway (Indiana) | 237.72 mi (382.57 km) |
| Creve Coeur to Spencer (Iowa) | 395.49 mi (636.48 km) |
| Creve Coeur to Spokane (Washington) | 1,485.68 mi (2,390.96 km) |
| Creve Coeur to Spokane Valley (Washington) | 1,476.67 mi (2,376.48 km) |
