| Crest to Smyrna (Delaware) | 3,982.76 mi (6,409.63 km) |
| Crest to Smyrna (Georgia) | 4,602.76 mi (7,407.42 km) |
| Crest to Smyrna (Tennessee) | 4,598.80 mi (7,401.05 km) |
| Crest to Snellville (Georgia) | 4,580.26 mi (7,371.21 km) |
| Crest to Snoqualmie (Washington) | 5,294.29 mi (8,520.34 km) |
| Crest to Snyder (Texas) | 5,355.59 mi (8,618.99 km) |
| Crest to Socastee (South Carolina) | 4,362.54 mi (7,020.84 km) |
| Crest to Socorro (Texas) | 5,623.89 mi (9,050.78 km) |
| Crest to Soddy-Daisy (Tennessee) | 4,570.93 mi (7,356.20 km) |
| Crest to Solana Beach (California) | 5,960.89 mi (9,593.13 km) |
| Crest to Soledad (California) | 5,904.64 mi (9,502.59 km) |
| Crest to Solon (Ohio) | 4,153.99 mi (6,685.20 km) |
| Crest to Somers Point (New Jersey) | 3,937.33 mi (6,336.53 km) |
| Crest to Somerset (Kentucky) | 4,467.65 mi (7,189.99 km) |
| Crest to Somerset (New Jersey) | 3,887.57 mi (6,256.43 km) |
