| Costa Mesa to Superior (Colorado) | 826.67 mi (1,330.40 km) |
| Costa Mesa to Superior (Wisconsin) | 1,622.07 mi (2,610.47 km) |
| Costa Mesa to Surprise (Arizona) | 314.03 mi (505.38 km) |
| Costa Mesa to Susanville (California) | 489.75 mi (788.18 km) |
| Costa Mesa to Sussex (Wisconsin) | 1,724.23 mi (2,774.88 km) |
| Costa Mesa to Suwanee (Georgia) | 1,933.09 mi (3,111.01 km) |
| Costa Mesa to Swansea (Illinois) | 1,588.52 mi (2,556.48 km) |
| Costa Mesa to Sweetwater (Florida) | 2,303.98 mi (3,707.89 km) |
| Costa Mesa to Sweetwater (Texas) | 1,015.68 mi (1,634.59 km) |
| Costa Mesa to Sycamore (Illinois) | 1,685.87 mi (2,713.15 km) |
| Costa Mesa to Sylacauga (Alabama) | 1,818.47 mi (2,926.54 km) |
| Costa Mesa to Sylvania (Ohio) | 1,936.70 mi (3,116.82 km) |
| Costa Mesa to Syosset (New York) | 2,465.23 mi (3,967.41 km) |
| Costa Mesa to Syracuse (New York) | 2,327.86 mi (3,746.32 km) |
| Costa Mesa to Syracuse (Utah) | 604.40 mi (972.68 km) |
