| Costa Mesa to Southern Pines (North Carolina) | 2,183.44 mi (3,513.90 km) |
| Costa Mesa to Southfield (Michigan) | 1,965.05 mi (3,162.44 km) |
| Costa Mesa to Southgate (Michigan) | 1,965.81 mi (3,163.67 km) |
| Costa Mesa to Southlake (Texas) | 1,197.90 mi (1,927.83 km) |
| Costa Mesa to Spanaway (Washington) | 957.44 mi (1,540.86 km) |
| Costa Mesa to Spanish Fork (Utah) | 563.90 mi (907.51 km) |
| Costa Mesa to Spanish Lake (Missouri) | 1,577.73 mi (2,539.10 km) |
| Costa Mesa to Spanish Springs (Nevada) | 425.14 mi (684.19 km) |
| Costa Mesa to Sparks (Nevada) | 420.16 mi (676.19 km) |
| Costa Mesa to Spartanburg (South Carolina) | 2,044.81 mi (3,290.80 km) |
| Costa Mesa to Spearfish (South Dakota) | 1,060.60 mi (1,706.87 km) |
| Costa Mesa to Speedway (Indiana) | 1,793.78 mi (2,886.81 km) |
| Costa Mesa to Spencer (Iowa) | 1,389.18 mi (2,235.66 km) |
| Costa Mesa to Spokane (Washington) | 967.66 mi (1,557.29 km) |
| Costa Mesa to Spokane Valley (Washington) | 967.67 mi (1,557.31 km) |
