| Costa Mesa to Silver Firs (Washington) | 1,005.23 mi (1,617.76 km) |
| Costa Mesa to Silver Spring (Maryland) | 2,286.31 mi (3,679.47 km) |
| Costa Mesa to Silver Springs Shores (Florida) | 2,129.86 mi (3,427.68 km) |
| Costa Mesa to Silverdale (Washington) | 998.54 mi (1,607.00 km) |
| Costa Mesa to Silverton (Oregon) | 824.91 mi (1,327.56 km) |
| Costa Mesa to Simi Valley (California) | 63.31 mi (101.89 km) |
| Costa Mesa to Simpsonville (South Carolina) | 2,028.28 mi (3,264.21 km) |
| Costa Mesa to Sioux City (Iowa) | 1,314.72 mi (2,115.83 km) |
| Costa Mesa to Sioux Falls (South Dakota) | 1,325.98 mi (2,133.95 km) |
| Costa Mesa to Skokie (Illinois) | 1,733.99 mi (2,790.59 km) |
| Costa Mesa to Sleepy Hollow (New York) | 2,445.02 mi (3,934.88 km) |
| Costa Mesa to Slidell (Louisiana) | 1,659.95 mi (2,671.43 km) |
| Costa Mesa to Smithfield (North Carolina) | 2,238.94 mi (3,603.23 km) |
| Costa Mesa to Smithfield (Utah) | 654.62 mi (1,053.51 km) |
| Costa Mesa to Smithville (Missouri) | 1,350.37 mi (2,173.21 km) |
