| Costa Mesa to Seymour (Tennessee) | 1,934.19 mi (3,112.78 km) |
| Costa Mesa to Shady Hills (Florida) | 2,114.66 mi (3,403.22 km) |
| Costa Mesa to Shafter (California) | 145.10 mi (233.51 km) |
| Costa Mesa to Shaker Heights (Ohio) | 2,046.74 mi (3,293.92 km) |
| Costa Mesa to Shakopee (Minnesota) | 1,507.77 mi (2,426.52 km) |
| Costa Mesa to Sharon (Pennsylvania) | 2,100.34 mi (3,380.17 km) |
| Costa Mesa to Sharonville (Ohio) | 1,890.29 mi (3,042.13 km) |
| Costa Mesa to Shasta Lake (California) | 543.07 mi (873.99 km) |
| Costa Mesa to Shawnee (Kansas) | 1,333.86 mi (2,146.64 km) |
| Costa Mesa to Shawnee (Oklahoma) | 1,196.15 mi (1,925.02 km) |
| Costa Mesa to Sheboygan (Wisconsin) | 1,757.44 mi (2,828.33 km) |
| Costa Mesa to Shelby (North Carolina) | 2,062.85 mi (3,319.84 km) |
| Costa Mesa to Shelbyville (Indiana) | 1,817.69 mi (2,925.29 km) |
| Costa Mesa to Shelbyville (Kentucky) | 1,845.34 mi (2,969.79 km) |
| Costa Mesa to Shelbyville (Tennessee) | 1,786.62 mi (2,875.29 km) |
