| Costa Mesa to Scottsboro (Alabama) | 1,815.53 mi (2,921.82 km) |
| Costa Mesa to Scottsdale (Arizona) | 347.72 mi (559.61 km) |
| Costa Mesa to Scranton (Pennsylvania) | 2,351.32 mi (3,784.08 km) |
| Costa Mesa to Seabrook (Maryland) | 2,295.55 mi (3,694.33 km) |
| Costa Mesa to Seabrook (Texas) | 1,373.06 mi (2,209.72 km) |
| Costa Mesa to Seaford (New York) | 2,466.31 mi (3,969.14 km) |
| Costa Mesa to Seagoville (Texas) | 1,235.73 mi (1,988.72 km) |
| Costa Mesa to Seal Beach (California) | 10.90 mi (17.55 km) |
| Costa Mesa to Searcy (Arkansas) | 1,491.11 mi (2,399.71 km) |
| Costa Mesa to Seaside (California) | 300.64 mi (483.83 km) |
| Costa Mesa to SeaTac (Washington) | 978.96 mi (1,575.48 km) |
| Costa Mesa to Seattle (Washington) | 991.06 mi (1,594.96 km) |
| Costa Mesa to Sebastian (Florida) | 2,247.65 mi (3,617.24 km) |
| Costa Mesa to Sebring (Florida) | 2,199.05 mi (3,539.02 km) |
| Costa Mesa to Secaucus (New Jersey) | 2,435.90 mi (3,920.20 km) |
