| Costa Mesa to Santa Rosa (California) | 424.97 mi (683.92 km) |
| Costa Mesa to Santaquin (Utah) | 551.31 mi (887.24 km) |
| Costa Mesa to Santee (California) | 77.58 mi (124.86 km) |
| Costa Mesa to Sapulpa (Oklahoma) | 1,244.91 mi (2,003.50 km) |
| Costa Mesa to Saraland (Alabama) | 1,746.76 mi (2,811.14 km) |
| Costa Mesa to Sarasota (Florida) | 2,139.72 mi (3,443.55 km) |
| Costa Mesa to Sarasota Springs (Florida) | 2,144.39 mi (3,451.06 km) |
| Costa Mesa to Saratoga (California) | 339.76 mi (546.80 km) |
| Costa Mesa to Saratoga Springs (New York) | 2,447.33 mi (3,938.59 km) |
| Costa Mesa to Saratoga Springs (Utah) | 567.51 mi (913.32 km) |
| Costa Mesa to Sartell (Minnesota) | 1,498.01 mi (2,410.81 km) |
| Costa Mesa to Satellite Beach (Florida) | 2,231.60 mi (3,591.41 km) |
| Costa Mesa to Sauk Rapids (Minnesota) | 1,500.32 mi (2,414.54 km) |
| Costa Mesa to Sault Ste. Marie (Michigan) | 1,962.12 mi (3,157.72 km) |
| Costa Mesa to Savage (Minnesota) | 1,512.43 mi (2,434.03 km) |
