| Costa Mesa to Sanford (Maine) | 2,599.11 mi (4,182.86 km) |
| Costa Mesa to Sanford (North Carolina) | 2,193.14 mi (3,529.52 km) |
| Costa Mesa to Sanger (California) | 229.15 mi (368.78 km) |
| Costa Mesa to Santa Ana (California) | 5.17 mi (8.31 km) |
| Costa Mesa to Santa Barbara (California) | 116.05 mi (186.77 km) |
| Costa Mesa to Santa Clara (California) | 342.38 mi (551.00 km) |
| Costa Mesa to Santa Clara (Oregon) | 774.18 mi (1,245.92 km) |
| Costa Mesa to Santa Clarita (California) | 61.68 mi (99.27 km) |
| Costa Mesa to Santa Cruz (California) | 326.04 mi (524.71 km) |
| Costa Mesa to Santa Fe (New Mexico) | 691.46 mi (1,112.80 km) |
| Costa Mesa to Santa Fe (Texas) | 1,372.64 mi (2,209.06 km) |
| Costa Mesa to Santa Fe Springs (California) | 20.28 mi (32.65 km) |
| Costa Mesa to Santa Maria (California) | 168.83 mi (271.70 km) |
| Costa Mesa to Santa Monica (California) | 40.84 mi (65.73 km) |
| Costa Mesa to Santa Paula (California) | 81.32 mi (130.86 km) |
