| Costa Mesa to San Luis Obispo (California) | 191.98 mi (308.96 km) |
| Costa Mesa to San Marcos (California) | 56.28 mi (90.58 km) |
| Costa Mesa to San Marcos (Texas) | 1,200.36 mi (1,931.79 km) |
| Costa Mesa to San Marino (California) | 33.50 mi (53.92 km) |
| Costa Mesa to San Mateo (California) | 364.76 mi (587.03 km) |
| Costa Mesa to San Pablo (California) | 386.79 mi (622.49 km) |
| Costa Mesa to San Rafael (California) | 394.72 mi (635.25 km) |
| Costa Mesa to San Ramon (California) | 361.87 mi (582.38 km) |
| Costa Mesa to San Tan Valley (Arizona) | 367.71 mi (591.78 km) |
| Costa Mesa to Sand Springs (Oklahoma) | 1,243.55 mi (2,001.30 km) |
| Costa Mesa to Sandusky (Ohio) | 1,987.06 mi (3,197.86 km) |
| Costa Mesa to Sandy (Oregon) | 842.85 mi (1,356.43 km) |
| Costa Mesa to Sandy (Utah) | 582.01 mi (936.65 km) |
| Costa Mesa to Sandy Springs (Georgia) | 1,917.24 mi (3,085.50 km) |
| Costa Mesa to Sanford (Florida) | 2,179.28 mi (3,507.21 km) |
