| Costa Mesa to Salisbury (New York) | 2,462.44 mi (3,962.92 km) |
| Costa Mesa to Salisbury (North Carolina) | 2,118.34 mi (3,409.14 km) |
| Costa Mesa to Salmon Creek (Washington) | 869.16 mi (1,398.78 km) |
| Costa Mesa to Salt Lake City (Utah) | 591.03 mi (951.16 km) |
| Costa Mesa to Sammamish (Washington) | 986.46 mi (1,587.56 km) |
| Costa Mesa to San Angelo (Texas) | 1,027.28 mi (1,653.24 km) |
| Costa Mesa to San Anselmo (California) | 396.05 mi (637.38 km) |
| Costa Mesa to San Antonio (Texas) | 1,175.87 mi (1,892.37 km) |
| Costa Mesa to San Benito (Texas) | 1,318.00 mi (2,121.11 km) |
| Costa Mesa to San Bernardino (California) | 48.35 mi (77.81 km) |
| Costa Mesa to San Bruno (California) | 372.95 mi (600.20 km) |
| Costa Mesa to San Buenaventura (California) | 86.39 mi (139.04 km) |
| Costa Mesa to San Carlos (California) | 360.39 mi (579.99 km) |
| Costa Mesa to San Carlos Park (Florida) | 2,202.85 mi (3,545.14 km) |
| Costa Mesa to San Clemente (California) | 23.01 mi (37.03 km) |
